Development of chronic tests for endocrine active chemicals. Part 2. An extended fish early-life stage test for androgenic active chemicals in the fathead minnow (Pimephales promelas)

R. Bogers, S. de Vries-Buitenweg, M. Gils, E. Baltussen, A. Hargreaves, B. van de Waart, D. de Roode, J. Legler, A.J. Murk

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The Endocrine Modulators Study Group (EMSG) of the European Chemical Industry has proposed an extended fish early-life stage (ELS) test based on OECD test guideline 210 in combination with a fish pair-breeding reproduction study as a possible alternative for fish full life cycle testing. In this paper the androgen methyldihydrotestosterone (MDHT) was tested in an extended ELS test with fathead minnow supplementary to such a test with the weak estrogen 4-tert-pentylphenol (4TPP). Main endpoints were secondary sexual characteristics (SSC), plasma vitellogenin (VTG) induction and gonadal development. Early blastula embryos were exposed to 0, 0.10, 0.32 and 1.0 μg MDHT l
Original languageEnglish
Pages (from-to)119-130
Number of pages12
JournalAquatic Toxicology
Volume80
DOIs
Publication statusPublished - 2006

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